Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.
Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.
Study Type
OBSERVATIONAL
Enrollment
1,080
Comparison between isoflurane and propofol, Retrospective study
Samsung medical center
Seoul, South Korea
CK-MB, CRP
Comparison of CK-MB and CRP values between propofol and isoflurane groups on postoperative day, POD1 and POD 2
Time frame: Change from preoperative value in CK-MR and CRP at Postoperative day(POD), POD 1 and 2
Clinical adverse outcomes
clinical adverse outcomes until postoperative 1 year
Time frame: until 1 year after OPCAB
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