Resistance type exercise training has been shown to be a potent stimulus to increase skeletal muscle mass and strength in healthy men. Furthermore, timed protein intake is also known to affect the muscle adaptive response following exercise. Whether timed protein intake could augment the increase in muscle fiber size and/or satellite cell content following long-term exercise intervention remains to be established. We hypothesize that protein supplementation before sleep, on both training and non-training days, during a 12 week resistance training program further increases type II muscle fibre cross sectional area when compared to the placebo group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
44
Maastricht University
Maastricht, Limburg, Netherlands
Skeletal muscle fiber size
Skeletal muscle fiber size will be assessed by muscle biopsy sampling before, during and after the 12 wks intervention period. Muscle fiber size will be expressed in µm2
Time frame: 12 weeks
Quadriceps cross-sectional area
Quadriceps cross-sectional area will be assessed by CT-scan before and after the 12 wks intervention period. Quadriceps cross-sectional area will be expressed in cm2
Time frame: 12 weeks
Whole body en regional body composition
Body composition (whole-body as well as regional) well be determined by DXA-scan performed before and after the 12 wks intervention period. Results will be expressed in kilograms
Time frame: 12 weeks
1RM strength
Maximum muscle strength will be assessed before, during and after 12 wks of exercise training by means of a 1 rep max test and will be expressed in kilograms.
Time frame: 12 weeks
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