Optimizing IVF Treatment - the Impact of Time-lapse Culture and Preimplantation Factor (PIF) on Embryo Development.

Regionshospitalet Viborg, Skive100 enrolled

Overview

The aims of this study are to evaluate: 1. the possible effect of time-lapse culture from day zero (day of oocyte retrieval) on fertilisation rates and embryo quality in standard IVF. 2. the association between PIF status in embryo culture medium and embryo quality assessed by standard subjective parameters and morphokinetic development.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

100

Conditions

In Vitro Fertilization Assisted Reproductive Techniques

Interventions

Day 0 denudation and time lapse culture on IVF-oocytes.PROCEDURE

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Standard IVF treatment * Body mass Index (BMI) between 18 and 30 * couples in which the male partner has normal sperm concentration and motility according to the World Health Organization (WHO, 2010) Exclusion Criteria: \- Patients with less than four oocytes

Locations (1)

The Fertility Clinic Skive

Skive, Denmark

Outcomes

Primary Outcomes

Embryo Quality

Time frame: Day 0-5 after oocyte pick-up

Secondary Outcomes

Fertilisation rate

Time frame: Day 1 after oocyte pick-up

Data from ClinicalTrials.gov

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