The aim of this prospective registration and translational research study is to evaluate the praevalence of BRCA regarding germline and somatic mutations.
Explorative analysis will be performed.
Study Type
OBSERVATIONAL
Enrollment
530
Charité - Universitätsmedizin Berlin
Berlin, Germany
Universitätsklinik Carl Gustav Carus
Dresden, Germany
Germline alterations in BRCA1/2 (yes/no) and other ovarian cancer predisposing genes (yes/no; if yes which)
Time frame: once per sample
Results of Immunohistochemistry in tumor samples
Time frame: once per sample
Somatic alterations in BRCA1/2 (yes/no) and other ovarian cancer predisposing genes (yes/no; if yes which)
Time frame: once per sample
BRCAness tumor phenotype in ovarian cancer (yes/no).
Time frame: once per sample
Differences of tumor samples from primary and relapsed disease
Time frame: once per sample for each stage of disease
Patient Survey for perspectives and satisfaction regarding testing and counseling
3 questions
Time frame: once after BRCA result is available
Determining the correlation of genetic alterations, cancer treatments, overall survival, progression-free survival and occurrence of new malignancies
Time frame: once
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
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