Biomarkers in Saliva in Children With Juvenil Idiopathic Arthritis

Overview

Purpose and aims This as a pilot study that aims to investigate which inflammatory biomarkers can be found in saliva in children with Juvenile Idiopathic Arthritis (JIA). The hypothesis is that children with JIA will show a different pattern of inflammatory biomarkers in saliva than healthy Children. The null hypothesis is that there are no differences.

This is a comparison between 100 children with JIA and 100 healthy children. Saliva will be collected and analyzed with respect to biomarkers. One-hundred consecutive patients with active JIA, as diagnosed by the Department of Pediatric Rheumatology, Astrid Lindgrens Barnsjukhus, Karolinska University Hospital will be included. Inclusion criteria are: * age between 7 and 14 years * a diagnosis of JIA according to the International League of Associations for rheumatology Exclusion criteria are: * current malignancies * TMJ surgery or trauma within two years * recent intra-articular glucocorticoid injection in TMJ (within 1 month) * other conditions or diseases than JIA that may cause orofacial pain. The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1. The control group of 100 age and sex matched healthy children will be included at Folktandvården Stockholms Län AB. Inclusion criteria are: • age between 7 and 14 years Exclusion criteria are: * current malignancies * TMJ surgery or trauma within two years * recent intra-articular glucocorticoid injection in TMJ (within 1 month) * A diagnosis of JIA * other conditions or diseases than JIA that may cause orofacial pain. The parents of the patients and/or the patients will give their verbal and written informed consent to participate in the study according to the permission from the regional ethical committee 2011/2:1.

Conditions

Eligibility

Locations (1)

Outcomes