Comparison of Effect on Quality of Recovery Outcome Between Systemic Lidocaine and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy

Yonsei University8 enrolled

Overview

The primary purpose of this study is to compare the effect of lidocaine and dexamethasone on postoperative quality of recovery after laparoscopic cholecystectomy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Gallbladder Polyp Asymptomatic Gallstones Without Cholecystitis

Interventions

LidocaineDRUG

Lidocaine 2mg Kg-1 in normal saline (total volume 25mL) was infused after tracheal intubation, and lidocaine was infused at the rate of lidocaine 2mg Kg-1 h-1 (0.2 ml Kg-1 h-1, equivalent volume as normal saline in dexamethasone group) until the end of surgery (at the time of skin closure).

DexamethasoneDRUG

Dexamethasone 8mg in normal saline (total volume 25mL) was infused after tracheal intubation, and normal saline was continuously infused at the rate of 0.2 ml Kg-1 h-1 until the end of surgery (at the time of skin closure).

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I-II patients aged between 20 and 65 year undergoing laparoscopic cholecystectomy due to gallbladder polyp or asymptomatic gallstones without cholecystitis Exclusion Criteria: 1. Steroid therapy or immunocompromised patients 2. Diabetes mellitus 3. Allergy to lidocaine or dexamethasone 4. Severe renal dysfunction (serum creatinine more than 1.6mg/dl) 5. Severe liver disease ( liver enzymes more than two times normal values) 6. History of atrioventricular block 7. Have a difficulty in understanding QoR-40 (40-item quality-of-recovery scoring system) or Korean language 8. History of physicologic disease

Locations (1)

Department of Surgery, Yonsei University College of Medicine, Seoul, Korea

Seoul, South Korea

Outcomes

Primary Outcomes

QoR-40 score

40-item quality-of-recovery scoring system

Time frame: from baseline to 3 hours on the day after surgery

Secondary Outcomes

Incidence and severity of postoperative nausea and vomiting

10 cm-visual analogue scale

Time frame: from baseline to 3 hours on the day after surgery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.