Effects of Different Doses of Dexmedetomidine on Postoperative Cognitive Dysfunction in Elderly Hypertensive Patients

First Affiliated Hospital Xi'an Jiaotong University90 enrolled

Overview

The purpose of this study is to identify the effects of different doses of dexmedetomidine on postoperative cognitive dysfunction in elderly hypertensive patients

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Postoperative Cognitive Dysfunction

Interventions

dexmedetomidineDRUG

Experimental: Group A, Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.3µg.kg-1.h-1 until 30 minutes before end of operation

dexmedetomidineDRUG

Group B, Continuous pump infusion dexmedetomidine with loading dose at 0.8µg.kg-1 over 10 minutes,followed continuous pump infusion dexmedetomidine at 0.5µg.kg-1.h-1 until 30 minutes before end of operation

normal salineDRUG

Group C , Normal saline infusion will be given with the same infusion volume as group A and B

Eligibility

Sex: ALLMin age: 65 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent * Elective gastrointestinal surgery * American Society of Anesthesiologists class II to III * Aged between 65 and 80 years old * Weight between 45 and 75 kilogram,Body Mass Index between 19 and 24 kg.m-2 * With primary hypertension reaching or more than 1 year * Normal cognitive function,mini-mental state examination more than 27 Exclusion Criteria: * Severe arrhythmia,atrioventricular block and secondary hypertension * Liver and kidney dysfunction,pulmonary disease,endocrine disease * Suspected or confirmed difficult airway * Any disease or pathologic change will interfere study result * Inability to exchange with serious visual and hearing impairment * Long term use of sedative-hypnotic drugs and antidepressant drug * Addicted to alcohol, tobacco or drug * Neuromuscular disease * Suspected of malignant hyperthermia * Allergic to investigational products or with other contraindication * Participated in other study within 30 days

Outcomes

Primary Outcomes

Change from baseline to postoperation in cognitive function

Mini-mental State Examination

Time frame: One day before operation,third day after operation,sixth day after operaion

Change from baseline to postoperation in recent memory

Rey Auditory Verbal Learning Test

Time frame: One day before operation,third day after operation,sixth day after operation

Change from baseline to postoperation in visual space and directional force

Trail Making Test A,Trail Making Test B

Time frame: One day before operation,third day after operation,sixth day after operaion

Change from baseline to postoperation in attention

Digit Span Test

Time frame: One day before operation,third day after operation,sixth day after operaion

Change from baseline to postoperation in pain scores

Visual analog scales

Time frame: One day before operation,third day after operation,sixth day after operation

Change from baseline to postoperation in depression scale

Beck Depression Inventory

Time frame: One day before operation,third day after operation,sixth day after operation

Secondary Outcomes

The duration of operation

Time frame: From begining of cutting skin to the end of skin closure,an expected average of 3 hours

The blood volume during the operation

Data from ClinicalTrials.gov

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