Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function

CancerCare Manitoba42 enrolled

Overview

The is study will examine whether variation in clinical bleeding frequency and severity among boys with severe Hemophilia A (Factor VIII deficiency) is associated with variations in laboratory measurements of platelet activity.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Hemophilia A

Eligibility

Sex: MALEMin age: 3 YearsMax age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * documented circulating FVIII level of ≤1% * age 3 - 20 years * may be on primary or secondary prophylaxis * granting of informed consent Exclusion Criteria: * measurable inhibitor level at the time of enrollment * ingestion of aspirin/supplement known to influence platelet function within 14 days of blood sampling, or ibuprofen within 3 days

Locations (2)

CancerCare Manitoba

Winnipeg, Manitoba, Canada

The Hospital for Sick Children

Toronto, Ontario, Canada

Outcomes

Primary Outcomes

Procoagulant platelet-derived microparticle formation

Time frame: At time of enrollment

Platelet aggregation

Whole blood platelet aggregation responses

Time frame: At time of enrollment

Data from ClinicalTrials.gov

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