Safety and pharmacokinetics after oral single rising doses of BIIB 722 CL
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
71
Area under the concentration-time curve of the analyte in plasma (AUC)
Time frame: up to 96 hours after drug administration
Maximum measured concentration of the analyte in plasma (Cmax)
Time frame: up to 96 hours after drug administration
Time from dosing to the maximum concentration of the analyte in plasma (tmax)
Time frame: up to 96 hours after drug administration
Total mean residence time of the analyte in the body (MRTtot)
Time frame: up to 96 hours after drug administration
Total clearance of the analyte in plasma (CLtot/f)
Time frame: up to 96 hours after drug administration
Number of subjects with adverse events
Time frame: up to 96 hours after drug administration
Number of subjects with clinically significant findings in vital functions
Time frame: up to 96 hours after drug administration
Number of subjects with clinically significant findings in laboratory tests
Time frame: up to 96 hours after drug administration
Thrombocytic Na-H exchange (NHE-1) inhibition by AUC of pH recovery
Time frame: up to 24 hours after drug administration
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