In obese individuals cortisol production and secretion is increased but the underlying mechanism is not known. Obesity leads to a pathological activation of the innate immune system partly driven by tissue production of IL-1β. Furthermore, IL-1β is also known to stimulate the release of adrenocorticotropin hormone (ACTH). Therefore, the investigators hypothesise that in obese individuals tissue inflammation stimulates ACTH via IL-1β, thereby explaining the observed hypercortisolism.
Study Type
INTERVENTIONAL
Allocation
NA
Masking
NONE
Enrollment
76
Anakinra 100mg s.c. x 5
University Hopsital Basel
Basel, Switzerland
Morning cortisol levels
Time frame: 14 days
effect of anakinra/Kineret® on salivary cortisol, free urinary cortisol, and serum cortisol levels after an overnight dexamethasone suppression test
Time frame: 14 days
correlation between the percentage of body fat or body mass index, and suppression of cortisol levels after injection of anakinra/Kineret®
Time frame: 14 days
correlation between inflammatory parameters with cortisol levels
Time frame: 14 days
impact of anakinra/Kineret® on other pituitary and peripheral hormones, such as: ACTH, TSH, fT4, GH, IGF-1, LH, FSH, testosterone copeptin, IL-6, CRP, leukocyte count and body temperature.
impact of anakinra/Kineret® on other pituitary and peripheral hormones such as: ACTH, thyroid-stimulating Hormone (TSH), free thyroxine 4 (fT4), growth Hormone (GH), insulin like growth factor (IGF)-1, luteinizing Hormone (LH), follicle stimulating Hormone (FSH), testosterone copeptin, interleukin (IL)-6, C reactive protein (CRP), leukocyte count and body temperature.
Time frame: 14 days
comparison of 1mg and 2mg dexamethasone suppression test
Time frame: 4 weeks
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