We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.
The mechanism of catheter-related bladder discomfort is thought to be related to the muscarinic receptor. The adjuncts to reversal agents such as glycopyrrolate and atropine are known to block the muscarinic receptor in different ways. We want to evaluate the efficacy of the glycopyrrolate and atropine for the prevention of catheter-related bladder discomfort.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
76
Glycopyrrolate will be administered.
Atropine will be administered.
Seoul National University of Hospital
Seoul, Korea, Republic of, South Korea
RECRUITINGCatheter-related bladder discomfort
Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
Time frame: 1 hour postoperatively
Catheter-related bladder discomfort
Catheter-related bladder discomfort will be measured at 1 hour postoperatively (0:none, 1:mild, 2:moderate, 3:severe).
Time frame: 0, 6 and 24 hour postoperatively
Hemodynamic parameters
Mean blood pressure and heart rate will be measured at 0, 1, 5, 10 minute postoperatively. Measurement at 10 minute means Mean blood pressure and heart rate at the admission of post-anesthetic care unit.
Time frame: 0, 1, 5, 10 minute postoperatively
Nausea
Nausea will be measured at 0, 1, 6 and 24 hour postoperatively.
Time frame: 0, 1, 6 and 24 hour postoperatively
Vomiting
Vomiting will be measured at 0, 1, 6 and 24 hour postoperatively.
Time frame: 0, 1, 6 and 24 hour postoperatively
Dry mouth
Dry mouth will be measured at 0, 1, 6 and 24 hour postoperatively.
Time frame: 0, 1, 6 and 24 hour postoperatively
Flushing
Flushing will be measured at 0, 1, 6 and 24 hour postoperatively.
Time frame: 0, 1, 6 and 24 hour postoperatively
Blurred vision
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Blurred vision will be measured at 0, 1, 6 and 24 hour postoperatively.
Time frame: 0, 1, 6 and 24 hour postoperatively
Dizziness
Dizziness will be measured at 0, 1, 6 and 24 hour postoperatively.
Time frame: 0, 1, 6 and 24 hour postoperatively
Analgesics
The amount of analgesics will be measured at 0, 1, 6 and 24 hour postoperatively.
Time frame: 0, 1, 6 and 24 hour postoperatively