The Relationship Between Sleep and Glucose Tolerance in Prediabetes: the Role of GLP-1 in Short Sleepers

Ramathibodi Hospital51 enrolled

Overview

Hypothesis 1. Prediabetes patients who have insufficient sleep will have worse glucose tolerance than those with normal sleep duration. 2. Prediabetes patients with short sleep will have a delayed or reduced GLP-1 response to a standardized meal

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Prediabetes

Interventions

Oral glucose toleranceOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients with prediabetes (HbA1c 5.7-6.4% or history of fasting plasma glucose 100-125 mg/dl) who receive medical care at Ramathibodi Hospital 2. Age 18 or older 3. Can understand Thai (speaking, listening and reading) 4. Agree to participate by written informed consent Exclusion Criteria: 1. Those who depend on others for feeding (such as stroke patients) 2. Shift workers 3. History of congestive heart failure or low ejection fraction 4. Chronic obstructive pulmonary disease, end stage renal disease or chronic liver disease (AST or ALT \> 3 times the upper limit of normal) 5. Use of medications: opioids/ narcotics , alpha blockers (prazosin, doxazosin, terazosin), clonidine, methyldopa, nitroglycerin 6. Patients with permanent pacemaker 7. History of previous stroke

Locations (1)

Faculty of Medicine Ramathibodi Hospital

Bangkok, Thailand

Outcomes

Primary Outcomes

GLP-1 Levels in Response to Oral Glucose Tolerance Test

Prediabetes patients with and without short sleep will undergo an oral glucose tolerance test with measurement of GLP-1 levels

Time frame: 2 weeks

Data from ClinicalTrials.gov

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