Serum Neuroglobin and Nogo-A Concentrations in Acute Traumatic Brain Injury

Shanghai 6th People's Hospital34 enrolled

Overview

Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury. The investigators sought to examine the changes in serum neuroglobin and Nogo-A concentrations in patients with traumatic brain injury during the initial 96-h posttraumatic period and assessed the relation of neuroglobin and Nogo-A to Glasgow Coma Score and prognosis of such patients with traumatic brain injury.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Traumatic Brain Injury

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who suffered head trauma and whose highest abbreviated injury score (AIS) was 3 or less (other than head injury) * Patients who delivered to hospital within 4 h Exclusion Criteria: * Patients who suffered open injuries * Patients who had existing prior neurological disease * Patients whose serial serum samples could not be obtained * Patients less than 18 years of age * Patients who suffered severe life-threatening injury to organs other than the brain

Locations (1)

Shanghai Sixth People's Hospital

Shanghai, China

Outcomes

Primary Outcomes

Glasgow Outcome Scale scores

Glasgow Outcome Scale 1 = death; Glasgow Outcome Scale 2 = vegetative state; Glasgow Outcome Scale 3 = severe neurological deficit; Glasgow Outcome Scale 4 = mild neurological deficit and Glasgow Outcome Scale 5 = premorbid level of functioning or completely recovery. Unfavorable outcome was defined as a Glasgow Outcome Scale score of ≤ 3, and favorable outcome was defined as a Glasgow Outcome Scale score of \> 3.

Time frame: 6 months

Data from ClinicalTrials.gov

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