The aim of this study is to investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine.
The investigators will investigate the differences between the cardiac output and the cerebral blood-flow between a regional anesthesia (RA) and a general anesthesia (GA) in a randomized, controlled, single center study at the Medical University Innsbruck, Department of Anesthesia and Intensive Care Medicine. For this purpose patients with the need of a carotid endarterectomy (CEA) will be included and randomized either to the regional anesthesia (RA) or the general anesthesia (GA) group until a patient number of 45 in each group is achieved. The cardiac output and cerebral blood-flow via trans-cranial Doppler (TCD) will be measured at 6 time points: * T0 Baseline (after insertion of an arterial line) * T1 After induction of anesthesia, but before surgical start * T2 Two minutes after clamping the carotid artery * T3 Two minutes after shunt insertation of the carotid artery * T4 After reperfusion * T5 After completion of the skin suture
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
90
Regional anesthesia
General anesthesia
6x for 4 hours
Medical University Innsbruck
Innsbruck, Tyrol, Austria
Influence of anesthetic technique on cardiac output during carotid endarterectomy.
Number of participants: 90 patients Unit of measure: Cardiac index (l/m2) Cardiac output will be measured and compared at the following time points: * T0 Baseline (after insertion of an arterial line) * T1 After induction of anesthesia, but before surgical start * T2 Two minutes after clamping the carotid artery * T3 Two minutes after shunt insertation of the carotid artery * T4 After reperfusion * T5 After completion of the skin suture
Time frame: Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit
Influence of anesthetic technique on trans-cranial doppler flow during carotid endarterectomy.
Cerebral blood flow will be measured via trans-cranial Doppler (TCD) and compared at the following time points: * T0 Baseline (after insertion of an arterial line) * T1 After induction of anesthesia, but before surgical start * T2 Two minutes after clamping the carotid artery * T3 Two minutes after shunt insertation of the carotid artery * T4 After reperfusion * T5 After completion of the skin suture
Time frame: Change of cardiac output from Baseline to induction of anesthesia and up to 1 hour after admission to the intermediate care unit
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6 x 3 ml blood withdrawal (18 ml) within 4 hours
before operation, 8 hours, as done in clinical routine
perioperative, 4-6 times within 8 hours, as done in clinical routine
perioperative, 2-3 days, as done in clinical routine
perioperative, for 5 hours, as done in clinical routine
perioperative for 5 hours, as done in clinical routine