Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones

Inclusion Criteria: * 18 to 85 years of age (male and female) * Atrophic or hypotrophic metaphyseal-diaphyseal pseudarthrosis of long bones, confirmed radiographically. * Signed Informed Consent Form * The patient is able to understand the nature of the study Exclusion Criteria: * Suspicious of pseudarthrosis focus infection diagnosed by clinical inspection and blood analysis. * Positive serology for HIV (Anti-HIV I/II-Ac), Hepatitis B (HBsAg, HBcAc), Hepatitis C (Anti-HCV-Ac) or Syphilis Lúes (TP-Ac). * Significant abnormal laboratory tests that contraindicates patient's participation in the study. * Pregnant woman or without proper anticonceptive measures according to the investigator, or breath feeding * Smoker of more than 15 cigarettes a day * Congenital disorders of bones (hypophosphatemia), bone metabolic disorders associated to primary or secondary hypoparathyroidism. * Badly managed diabetes mellitus. * Patients diagnosed with peripheral arterial disorders * Previous therapeutic radiation (5 previous years) of the affected bone. * Neoplasia within the previous 5 years, or without remission * The patient is legally dependent * Participation in another clinical trial or treated with an investigational medicinal product the previous 30 days * Other pathologic conditions or circumstances that difficult participation in the study according to medical criteria * The patient does not accept to be followed-up for a period that could exceed the clinical trial length