A Phase 1, Open-Label Study of the Absorption, Metabolism, Excretion and Absolute Bioavailability of ALS-008176

Inclusion Criteria: * Body mass index 18.0 to 32.0 kg/m2 (inclusive) and a total body weight \>50 kg Exclusion Criteria: * Creatinine clearance as calculated by the Cockroft-Gault formula of less than 60 mL/min * Clinically significant abnormal biochemistry, haematology or urinalysis as judged by the investigator or the sponsor medical monitor. Reticulocyte count, haemoglobin and platelet counts must not be less than the lower limit of normal for the subject. * History of clinically significant cardiovascular, renal, hepatic, chronic respiratory, GI, haematological, neurological, endocrinological, immunological, musculoskeletal disease or any uncontrolled medical illness (eg active infection) or psychiatric disorder, as judged by the investigator or medical monitor. * Clinically significant abnormal electrocardiogram (ECG) findings