The aim of the investigation is to validate the SmartPhone-based 4-Reaction Choice Time Test (4CRT) as a measure for recovery of the psychomotor function in patients after general anesthesia. One hundred female patients, scheduled to ambulatory gynecological surgery in general anesthesia, will be randomized to the group with pharmacological anxiolytic premedication with midazolam (N=50) and to the group without midazolam (N=50). All patients will be monitored using 4CRT before and after standardized general anesthesia. The reaction time, measured with 4CRT is the primary outcome parameter of the investigation.
4CRT is a classical psychological test, used to measure the psychomotor speed. This test measures choice reaction time. The participants are instructed to respond by pressing the keys 1-4 of the keyboard, corresponding to the numbers, appearing on the screen of computer (PDA, SmartPhone). The average of the response latency, measured during the 10 trials is usually taken as 4CRT outcome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
124
The participants receive the pharmacological premedication before the surgery anyway
Department of Anesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Therapy
Dresden, Saxony, Germany
Change of four choice reaction time from baseline
One time immediately before the surgery and 6 times within 2 hours after the surgery for each participant
Time frame: One time before the surgery and 2 hours after the surgery
Concentration of midazolam in serum
Time frame: Within 2 hours after the surgery only in 40 (20 from each group) participants
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