Pharmacokinetic Study of MIN-101 in Healthy Subjects

Inclusion Criteria: * Healthy males (Part 1 and Part 2) or non-pregnant, non-lactating healthy females (Part 2 only) * Body mass index (BMI) of 18.0 to 30.0 kg/m2 * Must be CYP2D6 Extensive metabolizer * Must be willing and able to communicate and participate in the whole study * Must provide written informed consent * Must agree to use an adequate method of contraception Key Exclusion Criteria: * Subjects who have QTc \> 430 in male, \> 450 in female confirmed by a repeat ECG * Any family history of sudden cardiac death and Torsade de Points * No personal or family history of unexplained presyncope, syncope or orthostatic hypotension * History of any drug or alcohol abuse in the past 2 years * History or evidence of any medically diagnosed clinically significant psychiatric disorders * Suicidal tendencies or history of suicidal attempts * Regular alcohol consumption in males \>21 units per week and females \>14 units per week (1 unit = ½ pint beer, 25 mL of 40% spirit or a 125 mL glass of wine) * Current smokers and those who have smoked within the last 12 months. A breath carbon monoxide reading of greater than 10 ppm at screening * Females of childbearing potential who are pregnant or lactating (female subjects must have a negative urine pregnancy test at admission) * Clinically significant abnormal biochemistry, haematology or urinalysis as judged by the investigator * Positive drugs of abuse test result * Positive hepatitis B surface antigen (HBsAg), hepatitis C virus antibody (HCV Ab) or human immunodeficiency virus (HIV) results