CELTIC Bifurcation Study

Inclusion Criteria: * Male or female patient \>18 years old * Females of childbearing potential with a negative pregnancy test * Coronary artery disease requiring revascularization that is amenable to PCI * Medina 1,1,1 bifurcation lesion \[13\] with \>70% lesion in both the main vessel and the side branch by visual assessment * Main branch and side branch ≥ 2.5mm in diameter by visual assessment * Both vessels require stenting in the opinion of the operator Exclusion Criteria: * Acute myocardial infarction with ongoing ST-elevation * Cardiogenic shock * Lesion involves the left main coronary artery * Lesion involves bypass graft * Plan to treat \>1 other coronary vessel at the time of inclusion * Chronic total occlusion of any target vessel * Left ventricular ejection fraction \<20% * Requirement for ongoing haemodialysis * Life-expectancy limited to \<12 months due to co-morbid condition * Known allergy to Aspirin * Known allergy to Clopidorel and Prasugrel and Ticagrelor * Known allergy to stent drug elutant * Known allergy to any other component of either the Synergy II or Xience Xpedition stents systems * Ongoing participation in another investigational device or drug study * Inability to provide informed consent