The purpose of this study was to determine whether a fixed dose combination of indacaterol and glycopyrronium (QVA149) has an impact on night-time blood oxygen levels in Chronic Obstructive Pulmonary Disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
38
Delivered once daily via single-dose dry powder inhaler
Placebo delivered once daily via single-dose dry powder inhaler
Novartis Investigative Site
Aarhus, Denmark
Novartis Investigative Site
Hvidovre, Denmark
Novartis Investigative Site
Bergen, Norway
Novartis Investigative Site
Gothenburg, Sweden
Novartis Investigative Site
Mean Night-time Blood Oxygenation
The mean night-time blood oxygenation following 4 weeks administration of QVA149 compared to placebo was assessed. Night time oxygenation (SpO2) was measured using polygraphy.
Time frame: Post 4 weeks administration of QVA149, post 4 weeks administration of placebo
Percent of Time Spent During the Night Below 90 % in Blood Oxygen Saturation
The time during the night spent below 90 % in blood oxygen saturation following 4 weeks administration of QVA149 compared to placebo was assessed. Night time oxygenation (SpO2) was measured using polygraphy.
Time frame: Post 4 weeks administration of QVA149, post 4 weeks administration of placebo
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Uppsala, Sweden