In this study, consecutive patients with cryptogenic cirrhosis (NASH-related cirrhosis), coming to ILBS (Institute of Liver \& Biliary Sciences) OPD (Out patient Department) or getting admitted in the ward will be enrolled on fulfillment of inclusion/exclusion criteria and consent of the patient. These patients will be randomised to either metformin arm or conventional treatment arm. After enrollment these subjects will be monitored every three monthly for total of 12 months or till the primary endpoint is achieved. At the end of the study, outcome will be measured appropriately.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
86
Institute of Liver & Biliary Sciences
New Delhi, National Capital Territory of Delhi, India
Reduction of portal pressure
Time frame: 1 Year
Improvement in fibrosis(assessed by noninvasive methods like Fibroscan and Fib 4 index)
Time frame: 1 Year
Safety profile of the drugs like Random Blood Sugar (RBS) and serum lactate monitoring regularly.
Time frame: 1.5 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.