Radiolabeled Study of CC-122 in Healthy Subjects

Inclusion Criteria: * 1\. Healthy adult male of any race and between 18 years of age to 55 years of age, inclusive, at the time of signing the informed consent document. 2\. Understand and voluntarily sign an informed consent document before any study related assessments/procedures are performed. 3\. Able to adhere to the study visit schedule and other protocol requirements. 4. Must practice true abstinence or agree to use a condom (a latex condom is recommended) during sexual contact with a pregnant female or a female of childbearing potential while participating in the study and for at least 28 days following discontinuation of investigational product, even if he has undergone a successful vasectomy. 5\. Must agree to abide by the CC 122 Pregnancy Prevention Risk Management Plan 6. Must have a body mass index between 18 and 33 kg/m2, inclusive, at screening. 7\. Must be healthy as determined by the Investigator on the basis of medical history, physical exam, clinical laboratory test results, vital signs, and 12-lead electrocardiogram at screening: * Must be afebrile (febrile is defined as ≥ 38.5°C or 101.3°F) * Supine systolic blood pressure must be in the range of 90 to 140 mmHg, supine diastolic blood pressure must be in the range of 50 to 90 mmHg, and pulse rate must be in the range of 40 to 110 bpm * Normal or clinically acceptable 12 lead electrocardiogram, with a QTcF value ≤ 430 msec Exclusion Criteria: * 1\. History of any clinically significant and relevant neurological, gastrointestinal, renal, hepatic, cardiovascular, psychological, pulmonary, metabolic, endocrine, hematological, allergic disease, drug allergies (including a known hypersensitivity to a member of the class of IMiDs®), or other major disorders. 2\. Any condition, including the presence of clinically significant laboratory abnormalities, which places the subject at unacceptable risk if he were to participate in the study. 3\. Any condition that confounds the ability to interpret data from the study. 4. Exposed to an investigational drug (new chemical entity) within 30 days preceding dose administration, or five half lives of that investigational drug, if known (whichever is longer). 5\. Participation in more than one other radiolabeled investigational drug study within 12 months prior to check in. Note: The previous radiolabeled investigational drug must have been received more than 6 months prior to check in and the total planned exposure from this current study and the previous study must be within the recommended levels considered safe, per United States Code of Federal Regulations governing Protection of Human Subjects; radioactive drugs for certain research uses. 6\. Exposure to significant radiation (for example, serial X-ray or computed tomography scans, barium meal, current employment in a job requiring radiation exposure monitoring) within 12 months prior to check in. 7\. Used any prescribed systemic or topical medication (including but not limited to analgesics, anesthetics, etc) within 30 days of dose administration. 8\. Used any nonprescribed systemic or topical medication (including vitamin/mineral supplements, and herbal medicines) within 14 days of dose administration. 9\. Used cytochrome P450 3A inducers and/or inhibitors (including St. John's wort) within 30 days of dose administration. 10\. Received a live vaccination within 90 days of dose administration. 11. Has any surgical or medical conditions possibly affecting absorption, distribution, metabolism, and/or elimination, for example, bariatric procedure, or plans to have elective or medical procedures performed during the conduct of the trial. Prior appendectomy is acceptable, but prior cholecystectomy would result in exclusion from the study. 12\. Donated blood or plasma within 8 weeks before dose administration to a blood bank or blood donation center. 13\. History of drug abuse (as defined by the current version of the Diagnostic and Statistical Manual) within 2 years before dose administration, or positive drug screening test reflecting consumption of illicit drugs. 14\. History of alcohol abuse (as defined by the current version of the Diagnostic and Statistical Manual) within 2 years before dose administration, or positive alcohol screen. 15\. Known to have serum hepatitis or known to be a carrier of hepatitis B surface antigen or hepatitis C antibodies, or have a positive result to the test for HIV antibodies at screening. 16\. Smokes more than 10 cigarettes per day, or the equivalent in other tobacco products (self reported). 17\. Part of the clinical site staff personnel or family members of the clinical site staff. 18\. History of less than one to two bowel movements per day.