It has previously been shown in healthy overweight subjects, that table water including a defined amount of amino acids and chromium can decrease the postprandial glucose and insulin response. In this study, the effect of this table water on glucose excursions after a test meal containing a defined amount of available carbohydrates, protein and fat will be studied in patients with early type 2 diabetes or prediabetes according to guidelines that are treated with dietary measures or metformin only. The study will be conducted in a cross -over design, double blinded and placebo controlled including 20 participants. The primary endpoint of the study is the incremental area under the curve for plasma glucose (iAUCgluc) within 180 minutes after ingestion of the meal.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
20
Amino Acid and chromium - picolinate containg water ist taken with a test meal to study efects on glucose and insulin response.
Placebo drink ist taken with a test meal to study efects on glucose and insulin response.
Stoffwechselzentrum Rhein Pfalz
Mannheim, Germany
Area under the curve for Glucose
Area under the curve for glucose will be measured within 180 minutes after a test meal. Blood samples will be drawan at 8 timepoints during 180 minutes after ingestion of the test meal (0', 15', 30', 60', 90', 120', 150', 180').
Time frame: 0', 15', 30', 60', 90', 120', 150', 180' post test meal
AUC for insulin
Blood samples will be drawan at 8 timepoints during 180 minutes after ingestion of the test meal (0', 15', 30', 60', 90', 120', 150', 180').
Time frame: 0', 15', 30', 60', 90', 120', 150', 180' post test meal
Markers of inflammation
Blood samples will be drawan at 8 timepoints during 180 minutes after ingestion of the test meal (0', 15', 30', 60', 90', 120', 150', 180'). At these timepoints markers of inflammation will be measured (i.e. hsCRP and others)
Time frame: at 0', 15', 30', 60', 90', 120', 150', 180' post test meal
markers of lipid metabolism
Triglycerides, VLDL and other parameters of lipid metabolism are planned to be measured within 180 minutes after a test meal at 0', 15', 30', 60', 90', 120', 150', 180'.
Time frame: 0', 15', 30', 60', 90', 120', 150', 180' post test meal
Gut peptide hormones
Area under the curve for GLP-1, ghrelin, glucagone and GIP are measured within 180 minutes after the test meal.
Time frame: 0', 15', 30', 60', 90', 120', 150', 180' post test meal
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