Evaluation of diagnostic yield, feasibility and safety of transbronchial lung cryobiopsies done via bronchoscopy in the investigation of interstitial lung disease in comparison with videothoracoscopy-assisted surgical lung biopsy.
See above
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
50
Institut universitaire de cardiologie et de pneumologie de Québec
Québec, Canada
RECRUITINGOverall diagnostic yield of cryobiopsy specimens in interstitial lung disease
Number of cryobiopsy specimens from which a specific diagnosis of interstitial lung disease can be ascertained, as assessed by a two different pathologists blinded to the known final diagnosis.
Time frame: After biopsy (up to 24 months)
Complication rate of transbronchial cryobiopsy procedure
Assessment of complications related to cryoTBB: * pneumothorax * hemorrage * other complications
Time frame: Per-procedure and up to 24 hours after
Number of diagnostic specimens of cryoTBB in comparison with surgical lung biopsy specimen
Diagnostic concordance between cryobiopsy specimen analysis and corresponding surgical lung biopsy done in same subjects (same lung/lobe)
Time frame: After biopsy (up to 24 months)
Inter-observer agreement for cryobiopsy specimens
Interobserver agreement rate between two different pathologists blinded to subject history/radiological record and surgical lung biopsy specimen.
Time frame: After biopsy (up to 24 months)
Size of cryobiopsy specimen
Size of TBB cryobiopsy specimen measured by two different pathologists responsible for its interpretation.
Time frame: After biopsy (up to 24months)
Quality of cyrobiopsy specimens
Pathological quality score of TBB cryobiopsy specimens (artefacts, size, etc.) as assessed by two different pathologists responsible for their interpretation.
Time frame: After biopsy (up to 24 months)
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