Transcranial Magnetic Stimulation Treatment of Hoarding Disorder

Hartford Hospital1 enrolled

Overview

This is multiple baseline study including up to three participants with a primary diagnosis of hoarding disorder. All patients will receive unblinded repetitive transcranial magnetic stimulation study intervention.

Study assessments will be conducted at pre-baseline, weekly during baseline assessment (until a stable baseline is established, but not less than 2, 4, and 6 weeks for patients respectively), weekly during treatment, and at post-treatment. Magnetic resonance imaging (MRI) will be competed at pre-baseline, pre-treatment, and post-treatment. Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation using the Neurostar Therapy System for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC). Neuronavigation will direct coil placement over the DLPFC based upon structural MRI.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Hoarding

Interventions

Neurostar Transcranial Magnetic Stimulation Therapy SystemDEVICE

Treatment will entail daily (5 days/week) sessions of repetitive transcranial magnetic stimulation for 6 weeks employing right-sided, low frequency stimulation (1 Hz, 900 pulses/session for 30 sessions, 27,000 total pulses, intensity at 90% of the passive motor threshold) to the dorsolateral prefrontal cortex (DLPFC).

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed with hoarding disorder as primary disorder * Clinical Global Impression Score \> 3 * Saving Inventory-Revised score \> 39 Exclusion Criteria: * Any contraindication for participation in magnetic resonance imaging or transcranial magnetic stimulation * Severe and/or unstable medical or psychiatric condition that require immediate medical attention * Diagnosed with current major depressive episode * Currently taking psychiatric medication

Locations (1)

Hartford Hospital

Hartford, Connecticut, United States

Outcomes

Primary Outcomes

The Saving Inventory-Revised (SI-R) Total Score

The Saving Inventory-Revised (SI-R) is a self-report measure which includes 23 items assessing the severity of hoarding symptoms including difficulty discarding, acquiring, and clutter. The 23 items are added for a total score which ranges from 0 to 92 and with higher score indicating more severe hoarding symptoms.

Time frame: Pre-baseline, Post-baseline/Pre-treatment, Post-treatment, 2-Month Follow-up

Data from ClinicalTrials.gov

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