Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
130
ICM (Institut du cerveau et de la Moelle épinière)
Paris, France
Performance in the implicat task
Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre.
Time frame: day of inclusion (one day)
Performance in the Similitude task
Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.
Time frame: from inclusion to 4 months after inclusion
recording of EEG
EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials. Participants will come only once during one day a the research centre.
Time frame: day of inclusion (one day)
Analysis of MRI
T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls. Participants will come only once during one day at the research centre
Time frame: day of inclusion (one day)
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