Background: The wound healing promoting effect of negative wound pressure therapies (NWPT) takes place at the wound foam interface. Implementation of bioactive substances at this site represents a major research area for the development of future NWPT devices. Methods: Wound healing kinetics of pressure ulcers treated by vacuum assisted closure devices with or without the implementation of a thin interface of poly-N-acetyl glucosamine nanofibers (sNAG) was studied in a prospective randomized clinical trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
24
University Hospital Basel
Basel, Switzerland
Swiss Paraplegic Centre Nottwil
Nottwil, Switzerland
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
Time frame: up to 1 year
Wound surface area increase, respectively decrease as a measure of the effect of the studied devices on pressure ulcer healing
Time frame: up to 1 year
Wound Healing characteristics
Evaluation of granulation tissue formation in study groups
Time frame: up to 1 year
Wound Healing characteristics
Evaluation of wound epithelialization in study groups
Time frame: up to 1 year
Wound Healing characteristics
Evaluation of wound contraction in study groups
Time frame: up to 1 year
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