The purpose of this study is to compare the effect of lanthanum carbonate and calcium carbonate on the progression of coronary calcification and vascular endothelial dysfunction.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Osaka University Hospital
Suita, Osaka, Japan
Coronary artery calcification score
Time frame: 1 year
Endothelial function
Measured by EndoPAT™ (Itamar Medical Ltd.)
Time frame: 3 months
Serum bone metabolic markers
Bone specific alkaline phosphatase (BAP) and Tartrate-resistant acid phosphatase 5b (TRACP5b)
Time frame: 3 months
Serum bone metabolic markers
Bone specific alkaline phosphatase (BAP) and Tartrate-resistant acid phosphatase 5b (TRACP5b)
Time frame: 1 year
Serum concentrations of calcium, phosphate, intact parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D over time
Time frame: Up to 1 year
Estimated glomerular filtration rate over time
Time frame: Up to 1 year
Bone mineral density
Time frame: 1 year
Serum osteoprotegerin concentration
Time frame: 3 month
Serum osteoprotegerin concentration
Time frame: 1 year
Urinary alpha-Klotho to creatinine ratio
Time frame: 3 months
Urinary alpha-Klotho to creatinine ratio
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Time frame: 1 year
Urinary liver-type fatty acid binding protein (L-FABP) to creatinine ratio
Time frame: 3 months
Urinary liver-type fatty acid binding protein (L-FABP) to creatinine ratio
Time frame: 1 year
End-stage renal disease requiring renal replacement therapy
Time frame: Up to 1 year
Cardiovascular event requiring hospitalization
Acute myocardial infarction, angina pectoris, congestive heart failure, stroke, and peripheral vascular disease
Time frame: Up to 1 year
Death
Time frame: Up to 1 year