This observational, multi-center, open-label, prospective study will evaluate the relationship between serum interleukin-6 (IL-6) and C-reactive protein (CRP) levels and methoxy polyethylene glycol-epoetin beta dosage in participants with chronic kidney disease (CKD) on dialysis. Participants will be recruited who are on stable methoxy polyethylene glycol-epoetin beta maintenance therapy or will initiate therapy with methoxy polyethylene glycol-epoetin beta.
Study Type
OBSERVATIONAL
Enrollment
197
Methoxy polyethylene glycol-epoetin beta will be administered according to the usual standard of care and current best practice guidelines and will be observed during the study period.
Haemek Hospital; Nephrology
Afula, Israel
Barzilai Medical Centre ; Nephrology and Hypertension
Ashkelon, Israel
Correlation Coefficient (r) Between Serum C-Reactive Protein (CRP) Level and Methoxy Polyethylene Glycol-Epoetin Beta Dose
Regression analysis and Pearson correlation were used to calculate the correlation coefficient (r).
Time frame: Day 1
Correlation Coefficient (r) Between Serum Interleukin-6 (IL-6) Level and Methoxy Polyethylene Glycol-Epoetin Beta Dose
Regression analysis and Pearson correlation were used to calculate the correlation coefficient (r).
Time frame: Day 1
Percentage of Participants With Change in Methoxy Polyethylene Glycol-Epoetin Beta Dose at Month 6
Percentage of participants with change in methoxy polyethylene glycol-epoetin beta dose compared to baseline were reported as per the following categories: (a) No change, (b) Dose increase (1 to greater than \[\>\] 200 micrograms per kilogram \[mcg/kg\]), and (c) Dose decrease (1 to \>200 mcg/kg).
Time frame: Month 6
Change From Baseline in Methoxy Polyethylene Glycol-Epoetin Beta Dose at Month 6
Time frame: Baseline, Month 6
Serum CRP Level
Time frame: Baseline, Month 6
Serum IL-6 Level
Time frame: Baseline, Month 6
Correlation Coefficient (r) Between Serum CRP Level and Methoxy Polyethylene Glycol-Epoetin Beta Dose at Month 6
Regression analysis and Pearson correlation were used to calculate the correlation coefficient (r).
Time frame: Month 6
Correlation Coefficient (r) Between Serum IL-6 Level and Methoxy Polyethylene Glycol-Epoetin Beta Dose at Month 6
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Soroka Medical Center; Nephrology
Beersheba, Israel
Bnai Zion MC; Nephrology
Haifa, Israel
Carmel Medical Center; Nephrology
Haifa, Israel
Wolfson MC; Nephrology
Holon, Israel
Shaare Zedek Medical Center; Nrphrology Dept.
Jerusalem, Israel
Hadassah Medical Orgainastion; Nephrology
Jerusalem, Israel
Meir Medical Center; Nephrology Dept.
Kfar Saba, Israel
Western Galilee Hospital; Nrphrology Dept.
Nahariya, Israel
...and 8 more locations
Regression analysis and Pearson correlation were used to calculate the correlation coefficient (r).
Time frame: Month 6
Predictive Baseline Serum CRP Level for Participants Initiating Treatment With Methoxy Polyethylene Glycol-Epoetin Beta Dose
Time frame: Day 1
Predictive Baseline Serum IL-6 Level for Participants Initiating Treatment With Methoxy Polyethylene Glycol-Epoetin Beta Dose
Time frame: Day 1
Serum Hemoglobin Level
Time frame: Baseline, Month 6