CLE for Differential Diagnosis of IBD

University of Erlangen-Nürnberg Medical School105 enrolled

Overview

Differential diagnosis between Ulcerative Colitis (UC) and Crohn's disease (CD) is of pivotal importance for the management of Inflammatory Bowel Disease (IBD) as both entities involve specific therapeutic management strategies. Confocal Laser Endomicroscopy (CLE) allows on demand in vivo characterization of architectural and cellular details during endoscopy. Here, we assessed the efficacy of CLE to differentiate between UC and CD.

Study Type

OBSERVATIONAL

Enrollment

105

Conditions

Inflammatory Bowel Diseases

Interventions

EndomicroscopyDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * equal or above 18 years of age * ability to provide written informed consent * well-established diagnosis of CD or UC Exclusion Criteria: * history of IBD reclassification in the last 3 years * Boston Bowel Preparation Scale score's \< 2 in at least one of the three broad regions of the colon (i.e. rectum plus left side colon, transverse colon plus left and right flexures, right colon) * inability to provide written informed consent * severe uncontrolled coagulopathy * impaired renal function * pregnancy or breast feeding * active gastrointestinal bleeding * known allergy to fluorescein * residence in institutions

Locations (1)

University Hospital Erlangen

Erlangen, Germany

Outcomes

Primary Outcomes

Number of participants with IBD

Time frame: 4 years

Data from ClinicalTrials.gov

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