The purpose of this study is to investigate whether cardiac output (CO) and global end diastolic volume (GEDV) determined from the same thermodilution curve by EV1000 are mathematically coupled during the infusion of fluid or inotropic agents in critically ill patients.
Some fundamental questions remain unanswered about the mathematical analysis of the thermodilution curve and the physiological significance of the Global End Diastolic Volume ( GEDV ) . The mathematical derivation of the Global End Diastolic Volume (GEDV) is intimately linked with the Cardiac Output (CO), because EV1000, to calculate the GEDV, uses a formula in which the CO is the term "flow " for both the calculations of Volume Thermal Intra Thoracic (ITTV) and Lung Thermal volume (PTV) . The clinical validation of GEDV as an index of preload has been substantially based on measuring changes in GEDV and CO in response to the Fluid Challenge only in patients "volume responsive". In this scenario, GEDV and CO may show a close correlation only on the basis of their mathematical derivation.
Study Type
OBSERVATIONAL
Enrollment
20
Ospedali Riuniti
Foggia, FG, Italy
Change in Cardiac Output
To evaluate the change in cardiac function after therapeutic life-saving fluid resuscitation or vasopressor agent infusion, cardiac output will be assessed before and after 20 minutes starting infusion.
Time frame: Triplicate measurement in each subject before and 20 minutes after therapeutic infusion of fluids or vasopressor agents
Change in Global end diastolic volume
To evaluate the change in cardiac function after therapeutic life-saving fluid resuscitation or vasopressor agent infusion, global end diastolic volume will be assessed before and after 20 minutes starting infusion.
Time frame: Triplicate measurement in each subject before and 20 minutes after therapeutic infusion of fluids or vasopressor agents
Change Left ventricular volume
To evaluate the change in cardiac function after therapeutic, life-saving fluid resuscitation or vasopressor agent infusion, Left ventricular volume measurement with echocardiography will be evaluated before and after 20 minutes starting infusion.
Time frame: Before and 20 minutes after therapeutic infusion of fluids or vasopressor agents
Change Right ventricular volume
To evaluate the change in cardiac function after therapeutic life-saving fluid resuscitation or vasopressor agent infusion, Right Ventricular Volume measurement with echocardiography will be assessed before and after 20 minutes starting infusion.
Time frame: Before and 20 minutes after therapeutic infusion of fluids or vasopressor agents
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