The Effect of Norepinephrine and Dopamine on Radial Forearm Free Flap Tissue Oxygen Pressure and Microdialysate Metabolite Measurements

Tampere University Hospital25 enrolled

Overview

Vasopressors may be needed after head and neck microvascular reconstructions to maintain sufficient mean arterial pressure. This is crucial for the flap survival. The study hypothesis is that norepinephrine and dopamine used as vasopressors do not affect flap tissue oxygen level and microdialysate metabolites.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Head and Neck Cancer

Interventions

DopamineDRUG

NorepinephrineDRUG

no medicationOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * head and neck cancer patients having tumor ablation surgery and reconstruction with microvascular radial forearm flap Exclusion Criteria: * Patients having contraindications for the operation. * Patient refusal to participate in the study

Locations (1)

Tampere University Hospital

Tampere, P.O. Box 2000, Finland

Outcomes

Primary Outcomes

Evidence of clinically definite ischemia in a flap confirmed by changes in tissue oxygen pressure level and microdialysates metabolites

Time frame: 72 hours

Data from ClinicalTrials.gov

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