A double-blind, randomized, placebo controlled, multicenter, dose-finding phaseⅡclinical superiority study.
The trial is composed by 3 parts: 1) On-boat screening period for seasickness and safety tests will be evaluated in minus one day. 2) 4 weeks of washout period to eliminate the impact of voyage experience. 3) On-boat drug testing period. The subjects will be administered the drug before voyage. The seasickness symptoms will be evaluated during voyage. The safety test will be conducted before and after one day of on-boat testing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
180
placebo of levo phencynonate hydrochloride
levo phencynonate hydrochloride
Qingdao municipal hospital
Qingdao, Shandong, China
the symptoms of seasickness
Investigators should assess the symptoms of seasickness for subjects according to sea sickness severity scale.
Time frame: Two hours of voyage
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