Evaluation of Single-dose Pharmacokinetics of Intravenous Daptomycin in Patients With Thermal Injury

Inclusion Criteria: * Male or female of 18 years or older * Second and/or third degree thermal injury * Total body surface area burned ≥ 15% * Hospitalisation in the ICU for burn injured patients of the University Hospital Zürich * Probability of ICU stay of \>14 days * Written informed consent by the patient or in patients unable to be informed or to sign according to section 4.4 of the study protocol Exclusion Criteria: * Evidence of renal failure (Creatinine clearance \<30ml/min) or continuous renal replacement therapy such as continuous hemofiltration * History of muscle disease or skeletal muscle disorder * Creatine-phosphokinase (CPK) ≥ 5 times the upper limit of normal (ULN) * History of hypersensitivity to the drug * Pregnancy * Severe coagulation disorder