The trial is conducted in Europe. The aim of the trial is to investigate the influence of semaglutide on the pharmacokinetics (the exposure of the trial drug in the body) of single doses of atorvastatin and digoxin in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
31
Administered as a subcutaneous injection (s.c., under the skin). Initiated with weekly semaglutide dosing of 0.25 mg in the first 4 weeks, 0.5 mg the next 4 weeks, and 1.0 mg in the third 4 week period.
Oral administration. Digoxin will be given as 2 single doses of 0.5 mg.
Oral administration. Atorvastatin will be given as 2 single doses of 40 mg.
Novo Nordisk Investigational Site
Berlin, Germany
Area under the atorvastatin plasma concentration-time curve
Time frame: From time 0 to 72 hours after a single dose
Area under the digoxin plasma concentration-time curve
Time frame: From time 0 to 120 hours after a single dose
Maximum observed atorvastatin plasma concentration
Time frame: From time 0 to 72 hours after a single dose
Maximum observed digoxin plasma concentration
Time frame: From time 0 to 120 hours after a single dose
Number of treatment emergent AEs (TEAEs)
Time frame: From baseline (Visit 2, Day 1) to follow-up (Visit 12, 20 weeks after baseline)
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