Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen

Seoul National University Hospital120 enrolled

Overview

Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

TRIPLE

Enrollment

120

Conditions

Ibuprofen Remifentanil Hyperalgesia Pain, Postoperative

Interventions

high dose remifentanilDRUG

high dose remifentanil

IbuprofenDRUG

intravenous ibuprofen

low dose remifentanilDRUG

low dose remifentanil

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients scheduled for elective pancreaticoduodenectomy Exclusion Criteria: * Patients with chronic pain * Patients with psychiatric disease * Patients with nonsteroidal antiinflammatory drugs allergy * Patients with renail dysfunction * History of drug addiction * Pregnant patient * Inability to use a PCA device

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

cumulative morphine consumption

cumulative patient-controlled analgesia (PCA) morphine consumption

Time frame: postoperative 48 hours

Secondary Outcomes

Pain score

visual analogue scale

Time frame: postoperative 1, 3, 6,12, 24, 48 hours Pain score

Data from ClinicalTrials.gov

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