Individualized Blood Glucose Control in ICU. The CONTROLING Study. A Double Blinded Multicentric Randomized Study.

Inclusion Criteria: Patients are eligible for INCLUSION in the study if ALL the following criteria are met: * Patient is 18 year old or older; * At time of the patient's admission to the ICU the treating ICU specialist expects the patient will require treatment in the ICU that extends beyond the calendar day following the day of admission. Exclusion Criteria: * Patients will be EXCLUDED from the study if ONE or MORE of the following criteria are present: * Patient or legal surrogate decision maker does not accept the participation to the study; * Imminent death (anticipated in less than 48 hours); * The treating clinicians are not committed to full supportive care (no resuscitation, no renal replacement therapy limits in dose of vasoactive support); * Patient is expected to be eating before the end of the day following admission; * Admission in ICU for hypoglycemic encephalopathy or patient at risk for hypoglycaemia ( e.g. known insulin secreting tumour or history of unexplained or recurrent hypoglycaemia or fulminant hepatic failure); * If a patient has previously been enrolled in the CONTROLING Study (patients cannot be enrolled in the CONTROLING Study more than once).