immobilization of yoked extra-ocular muscles in the anophthalmic orbit, in conjunction with platelet-rich-plasma, will improve integration of viable adipocytes injected into orbital fat
Immobilization of tissue (graft, graft bed) is a prerequisite for tissue integration. Since yoked extra-ocular muscles continue to be stimulated by movements of the seeing eye after fat injection into the anophthalmic orbit, the use of botulinum toxin(s) can be used to prevent movement of the orbital tissue bed(s) and improve anchoring of injected fat. Platelet rich plasma may also improve fat cell anchoring by the action of fibrin on the adhesion process. This innovation builds on the results of IRB protocols 10.27 and 12.01 as registered with Clinical Trials.gov
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
6
fat injection with platelet-rich-plasma (PRP) after immobilizing the extraocular muscles with botulinum toxin
botulinum toxin used to immobilize extra-ocular muscles prior to fat injection.
autologous PRP is prepared with a dedicated centrifuge at the time of fat harvesting
New York Eye and Ear Infirmary
New York, New York, United States
Orbital volume
Augmentation of orbital volume accessed with clinical photographs and non-contrast MRI
Time frame: one year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.