CIMT and Plaque Assessment Findings in Subjects Undergoing Stress Echocardiography For Risk Stratification

Mayo Clinic73 enrolled

Overview

The purpose of this research study is to determine if carotid artery ultrasound scanning can provide additional information for determining cardiovascular risk in patients. Patients who agree to participate wil undergo non-invasive carotid intima-media thickness (CIMT) measurement and plaque assessment. Findings of CIMT will be compared to results of patient standard of care stress echocardiogram (SE) and of diastolic function. We hypothesize tht 1) in patients undergoing SE for inappropriate or uncertain indications, CIMT and plaque assessment will provide useful risk stratification beyond use of traditional risk factors; 2) CIMT findings will correlate with results of SE in terms of exercise capacity and 3) Exercise capacity will correlate with diastolic function.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Cardiovascular Risk Stratification Carotid Intima-media Thickness (CIMT)Stress Echocardiography (SE)

Interventions

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Asymptomatic * No prior cardiac history (MI, PTCA, CABG, angina) * No peripheral vascular disease * No history of stroke or TIA * Statins, antihypertensives, ASA treatment OK Exclusion Criteria: * History of CAD, CABG, PTCA, coronary or peripheral stenting * History of stroke/TIA/peripheral vascular disease * Inability to exercise on the treadmill * Unwilling/unable to sign informed consent * History of neck radiation or neck surgery or inability to obtain neck images * End stage renal disease * Preoperative evaluation * History of chest pain

Outcomes

Primary Outcomes

% Patients w/ Abnormal IMT vs. % Patients w/ Positive Ischemia on Stress Echocardiogram

We are comparing the % of patients with abnormal IMT defined as presence of plaque (= or \>1.5mm) or CIMT \>75% percentile for age, race, and gender compared to % of patients with positive ischemia on stress echocardiogram as defined by a new wall motion abnormality on echocardiogram with stress.

Time frame: Baseline