Eliminate Coronary Artery Disease

Inclusion Criteria: * Men 35-50 years of age * Women 45 - 59 years of age (must be sterile or \>2 years postmenopausal) * LDL cholesterol greater than 1.8 mmol/L (70 mg/dL) based on testing performed within 1 year * One risk factor for Coronary Heart Disease other than lipid abnormality: * Obesity and hypertension \[BP \>140 mmHg systolic and waist circumference \> 100 cm in men and \>90 cm in women\] * family history of premature myocardial infarction \[\<60 years\] * South Asian ethnic history * currently smoking Exclusion Criteria: * Currently taking cholesterol lowering medication * Qualify for cholesterol lowering medication based on current guidelines * Significant renal dysfunction (creatinine clearance \<30 ml/min) * Significant hepatic dysfunction (AST/ALT \>2.0 times upper limit of normal) * Active malignancy * Diabetes * Progressive or terminal illness, or other condition in which subject is unlikely to survive the study period * Known allergy, hypersensitivity (anaphylaxis) ar adverse reaction to any statin * Participation in a clinical trial (except observational studies) within previous 30 days * Received any investigation product within 30 days prior to participation in this clinical trial * Previously enrolled in this clinical trial