Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis

Meir Medical Center60 enrolled

Overview

PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.

Primary sclerosing cholangitis (PSC) and colitis are chronic inflammatory disorders with malignant potential. Telomerase is an enzyme complex that lengthens telomeres and has enhanced expression in numerous malignancies. In this study, we evaluated the telomerase gene copy number, telomere length, cells in senescence, aneuploidy and additional parameters of telomere dysfunction from peripheral blood lymphocytes of patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Primary Sclerosing Cholangitis Inflammatory Bowel Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * informed consent * documented PSC and inflammatory bowel disease Exclusion Criteria: * under 18 years, above 80 y * known active malignancy * decompensated cirrhosis * patients who cannot sign informed consent

Locations (1)

Meir Medical Center

Kfar Saba, Israel

RECRUITING

Outcomes

Primary Outcomes

Telomere length

Time frame: 1.5 years

Secondary Outcomes

number of cells with increased telomerase RNA component (TERC) expression

Time frame: 1.5 years

Central Contacts

Ido Laish, MD

CONTACT

+972-549477261 ido.laish@gmail.com

Data from ClinicalTrials.gov

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