Assessing Insulin Sensitivity and Diabetes Risk in Childhood Cancer Survivors Treated With Abdominal Irradiation

Memorial Sloan Kettering Cancer Center42 enrolled

Overview

The purpose of this study is to better understand the risk factors and causes of diabetes in people who received radiation to the abdomen as children. The investigators hope this information will allow them to improve how they screen people at risk for diabetes and how they treat patients in the future.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Childhood Cancer Survivors Treated With Abdominal Radiation

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of childhood cancer between 0-21 years of age * Prior treatment with abdominal radiation at MSKCC * Two or more years from completion of therapy * Records of cancer diagnosis and treatment (including radiation records) available Exclusion Criteria: * Known diagnosis of diabetes * Previous treatment with any radiation impacting the brain (cranial radiation, craniospinal radiation, total body irradiation) * Neurocognitive deficits that impair ability to give informed consent or assent * Patients predicted to have difficult intravenous access, who will likely require multiple venipuncture attempts

Locations (1)

Memorial Sloan Kettering Cancer Center

New York, New York, United States

Outcomes

Primary Outcomes

characterize β cell function

we will be able to estimate the proportion of patients with abnormalities of insulin sensitivity or β cell function, as assessed by the OGTT, to within ± 0.14.

Time frame: 2 years

insulin sensitivity

we will be able to estimate the proportion of patients with abnormalities of insulin sensitivity or β cell function, as assessed by the OGTT, to within ± 0.14.

Time frame: 2 years

Data from ClinicalTrials.gov

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