The purpose of this study is to find out the effect of low abdominal pressure vs. standard abdominal pressure on the cardiac and respiratory function of the patients undergoing laparoscopic colon surgery in Trendelenberg position. It was also designed to evaluate the effect of the degree of neuromuscular blockade on the surgical condition of the patients undergoing laparoscopic colon surgery in Trendelenberg position.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
131
Abdominal pressure maintained 12mmHg throughout laparoscopic colon surgery
Abdominal pressure maintained 8mmHg throughout laparoscopic colon surgery
Anesthesia induction with rocuronium 0.4mg/kg and maintenance with rocuronium 0.15mg/kg to maintain TOF 1-2 twitch
Anesthesia induction with rocuronium 0.8mg/kg → maintenance with rocuronium 0.3mg/kg to maintain PTC 1-2 twitch
Seoul National University Hospital
Seoul, South Korea
Cardiac Index
Cardiac index 30 min after onset of laparoscopy. The cardiac index was measured with an arterial waveform analysis system (FloTrac/EV1000, version 4.0; Edwards Life Sciences, Irvine, CA, USA) from the radial artery.
Time frame: 30 min after onset of laparoscopy
Mean Arterial Blood Pressure (MBP)
Mean arterial blood pressure measured during laparoscopic surgery. The mean arterial blood pressure was measured with an arterial waveform analysis system (FloTrac/EV1000, version 4.0; Edwards Life Sciences, Irvine, CA, USA) from the radial artery.
Time frame: 1, 30, 60, 90, and 120 minutes after onset of laparoscopy
Stroke Volume Index (SVI)
Stroke volume index during the surgery. The stroke volume index was measured with an arterial waveform analysis system (FloTrac/EV1000, version 4.0; Edwards Life Sciences, Irvine, CA, USA) from the radial artery.
Time frame: 1, 30, 60, 90, 120 min after onset of laparoscopy
PaO2
PaO2 measured during laparoscopic surgery. The PaO2 (arterial partial pressure of oxygen) was measured with the blood gas analyzer (GEM Premier 3000, Model 5700; Instrumentation Laboratory, Lexington, MA, USA).
Time frame: 1, 30, 60, 90, and 120 minutes after onset of laparoscopy
Pulmonary Compliance
Pulmonary compliance during laparoscopic surgery. The pulmonary compliance was calculated from the plateau and peak inspiratory pressures, positive end-expiratory pressure, and tidal volume measured with an anesthetic machine (Primus; Dräger, Lübeck, Germany).
Time frame: 1, 30, 60, 90, and 120 minutes after onset of laparoscopy
Surgical Rating Scale
The surgical rating scale was assessed by the surgeon and graded as a five-point scale: optimal, good, acceptable, poor, and extremely poor conditions.
Time frame: 1 min after laparoscopic procedure
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.