The purpose of this study is to establish normal Magnetic Resonance quantitative values (tissues stiffness, Apparent Diffusion Coefficient values and Blood Oxygen Level Determination values for both renal cortex and medullary tissues and total renal blood flow) for young Autosomal Dominant Polycystic Kidney Disease patients with normal renal function, and normal young adult controls without Autosomal Dominant Polycystic Kidney Disease and normal renal function. Hypothesis: Newer Magnetic Resonance quantitative imaging parameters (tissue stiffness, Apparent Diffusion Coefficient, Blood Oxygen Level Determination levels, Magnetization Transfer and renal blood flow) will have different values in young adult ADPKD patients as compared to normal volunteers.
Study Type
OBSERVATIONAL
Enrollment
20
Mayo Clinic
Rochester, Minnesota, United States
Evaluate renal tissue stiffness
The renal parenchymal tissue stiffness is measured in kilopascals with magnetic resonance elastography sequence.
Time frame: baseline
Magnetization transfer ratio
The magnetization transfer ratio of renal tissue is measured with magnetization transfer sequence and expressed as a ratio.
Time frame: baseline
Diffusion
Diffusion is quantified as apparent diffusion coefficient (x10-3/mm2) in renal tissue is measured with intravoxel incoherent motion imaging (IVIM) sequence and diffusion tensor imaging (DTI).
Time frame: baseline
Perfusion quantified as blood flow in mL/s.
Perfusion in the renal tissue is measured with arterial spin labeling sequence and phase contrast magnetic resonance angiography.
Time frame: baseline
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