Combined Effect of Dexamethasone and Paracetamol for Postoperative Sore Throat

Seoul National University Hospital242 enrolled

Overview

The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

The postoperative sore throat is a common complication after the general anesthesia which decreases the quality of life. Dexamethasone is known to effective for the prevention of postoperative sore throat. The combined effect of the dexamethasone and paracetamol for postoperative sore throat, however, is not investigated. The investigators want to evaluate the efficacy of the dexamethasone and paracetamol for the prevention of postoperative sore throat.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

242

Conditions

Pharyngitis

Interventions

DexamethasoneDRUG

Dexamethasone will be administered.

ParacetamolDRUG

Paracetamol will be administered.

Eligibility

Sex: ALLMin age: 19 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients scheduled for urologic surgery under general anesthesia * ASA I-III Exclusion Criteria: * Patients with recent sore throat * Patients with neck surgery * Patients with anticipated difficult airway * Patients with Mallampati grade 3 * Patients with severe cardiovascular or pulmonary disease * Patients with allergic history to dexamethasone or paracetamol * Patients with liver function disorder * Patients with liver disease

Locations (1)

Seolu National University of Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Postoperative sore throat

Postoperative sore throat after 1 hour postoperatively will be measured (0:none, 1:mild, 2:moderate, 3:severe)

Time frame: 1 hour postoperatively

Secondary Outcomes

Postoperative sore throat degree

Postoperative sore throat degree after 0, 1, 6, 24 hour postoperatively will be measured (11 points, 0:none, 10:worst imaginable).