NMES During the Day and Prior to Sleep

Maastricht University Medical Center16 enrolled

Overview

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and prior to sleep

In the present study, the effect of a bolus of intrinsically labeled milk directly after an hour of one-legged NMES (Neuromuscular Electrical Stimulation) will be studied under two conditions: during the day and immediately prior to sleep

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Sarcopenia

Interventions

Dietary protein plus NMES during the dayPROCEDURE

Neuromuscular electrical stimulation after a protein bolus, performed during the day

Dietary protein plus NMES prior to sleepPROCEDURE

Neuromuscular electrical stimulation after a protein bolus, performed prior to sleep

Eligibility

Sex: MALEMin age: 65 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 65-85 years * Male * 18.5 ≤ BMI ≤ 30.0 Exclusion Criteria: * Type II diabetes * All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery). * Use of anticoagulants, blood diseases, allergy for lidocaine * Use of NSAIDs (non-steroidal anti-inflammatory drugs) and acetylsalicylic acid * Patients suffering from PKU (Phenylketonuria) * Presence of implantable cardioverter defibrillator and/or pacemaker * Performed regular resistance type exercise in the past 6 months * Use of any tools to assist during walking (cane/ crutches/ walker) * (Partial) foot/ leg amputation

Locations (1)

Maastricht University Medical Centre +

Maastricht, Netherlands

Outcomes

Primary Outcomes

Incorporation of stable isotope amino acids into skeletal muscle tissue

Time frame: 4-8 hours in the postprandial phase

Secondary Outcomes

Plasma amino acid enrichment

Time frame: 4-8 hours in the postprandial phase

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.