The purpose of this study is to determine specific changes in muscle secretory profile (myokines, miRNA) in association with neurodegenerative disease progression and metabolic dysfunction. Next the investigators would like to determine the shift in the muscle secretory activity induced by regular exercise intervention, which the investigators think could be translated into the beneficial changes in clinical phenotypes, determined by neuroimaging, cognitive function tests and metabolic phenotyping.
Standard Operating Procedures for patient recruitment, data collection, data management, data analysis routinely used in University Hospital Bratislava and in Institute of Experimental Endocrinology Slovak Academy of Sciences will be employed. Statistical analysis will be employed to address the primary and secondary objectives, as specified in the study protocol.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
30
3 months exercise intervention program which is given 3-times per week, 60 min session duration, 65-75% repetition maximum or heart rate maximum, combined strength \& aerobic exercises
Univeristy Hospital in Bratislava
Bratislava, Slovakia
Inst. Exp. Endocrinology Slovak Acad Sci
Bratislava, Slovakia
muscle microRNAs and myokines
We will determine muscle bioactive secretory products (myokines \& miRNAs) that are regulated by acute bout of exercise in patients with neurodegenerative disease as well as in sedentary age, gender and BMI matched controls in association with their metabolic phenotype.
Time frame: up to 24 months
whole body energy metabolism
changes in whole body energy metabolism will be determined with indirect calorimetry. \& oral glucose tolerance test
Time frame: up to 24 months
cognitive function
exercise related changes in cognitive \& motoric functions will be determined with the aid of questionaires, and proton (1H)-magnetic resonance spectroscopy - brain imaging and spectroscopy
Time frame: up to 24 months
motoric function
Proton (1H)-magnetic resonance spectroscopy - brain imaging and spectroscopy, motoric - balance testing
Time frame: up to 30 months
Muscle functional tests
Dynamometry will be used to determine maximal voluntary contraction force and the rate of force development, and Phosphorus (31P)-magnetic resonance spectroscopy to measure muscle metabolism in vivo.
Time frame: up to 30 months
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