Comparison Between Perineural and Systemic Effect of Dexamethasone as an Adjuvant for Prolongation of Four Nerve Blocks With Bupivacaine in Total Knee Arthroplasty

Hillel Yaffe Medical Center90 enrolled

Overview

The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block in total knee arthroplasty. The aim of this study is to determine whether this is a systemic or local effect.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Analgesia Pain, Postoperative

Interventions

DexamethasoneDRUG

BupivacaineDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Pre-surgical total knee arthroplasty patients Exclusion Criteria: * Skin infection near block site * Allergy to local anesthetics * Peripheral neuropathy * Proven opioid dependency * Coagulopathy * Dementia

Locations (1)

Hillel Yaffe Medical Center

Hadera, Israel

Outcomes

Primary Outcomes

Efficacy Perineural DxaM

Duration of motor and sensory block

Time frame: One day

Secondary Outcomes

Efficacy of Systemic DxaM

Duration of motor and sensory block

Time frame: One day

Data from ClinicalTrials.gov

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