Study to Determine the Effects of Multiple-dose Omeprazole on the Single-dose Pharmacokinetics of Tipranavir (TPV) Coadministered With Ritonavir (RTV) in Healthy Adult Volunteers

Inclusion Criteria: 1. Male and female healthy volunteers between 18 and 60 years of age inclusive 2. Clinically normal medical history 3. Clinically normal findings on physical examination 4. Clinically normal laboratory values 5. Body Mass Index (BMI) between 18.5 and 30 kg/m2 inclusive 6. Ability to swallow large capsules without difficulty 7. Capable of comprehending and communicating effectively with the investigator and site staff 8. Signed and dated written informed consent form, in accordance with Ethics Committee and regulatory guidelines prior to trial participation 9. Willingness to abstain from ingesting substances which may alter plasma drug levels by interactions with the cytochrome P450 system during the 14 days of the study 10. Willingness to abstain from alcohol for 48 hours prior to Visit 2 and for the duration of the study 11. Willingness to abstain from ingesting grapefruit and grapefruit juice for 7 days before Visit 2 and for the duration of the study 12. Negative pregnancy test (β-hCG) 13. Negative HIV serology 14. Negative hepatitis serology Exclusion Criteria: 1. Any clinically significant disease (a significant disease is defined as a disease, which in the opinion of the investigator may either put the subject at risk because of participation in the study, or a disease which may influence the results of the study or the subject's ability to participate in the study) 2. Clinically significant abnormal baseline hematology, blood chemistry or urinalysis findings normal at Visit 2 3. Serum Alanine Aminotransferase (ALT), Aspartate Aminotransferase (AST), cholesterol, triglyceride or glucose greater than the upper limit of normal at Visit 2 4. Treatment with any investigational drug within 90 days prior to the first dose of study medication 5. Inability to adhere to the requirements of the protocol as assessed by the investigator 6. Prior TPV use 7. Subjects who are taking or have taken medications metabolized through the Cytochrome P-450 (CYP450) enzyme system within 30 days prior to Visit 2 8. Subject with a seated systolic blood pressure either \<100 mmHg or \>150 mmHg; resting heart rate either \<50 beats/min or \>100 beats/min 9. Subject with a history of any illness or allergy that in the investigator opinion might confound the results of the study, or pose additional risk to the subject with the administering of TPV/r or omeprazole 10. Subject who have had an acute illness within 14 days prior to Visit 2 11. Subject who are currently taking or have taken over-the-counter medications in the 14 days prior to Visit 2, or subjects who are currently taking any prescription medication 12. Known hypersensitivity to TPV, RTV, omeprazole or antiretroviral drugs (marketed or experimental use as part of clinical research studies) 13. Female subjects who are of reproductive potential and who are: * Pregnant or breast-feeding * Have a positive serum β-hCG (pregnancy test) at screening visit (Visit 1) * Have not been using a barrier contraceptive method for at least 60 days prior to Study Day 1 * Are not willing to use a reliable method of double-barrier contraception during the trial and for 30 days after completion or termination of the trial