Pharmacokinetic Interaction Between TRUVADA™ and BILR 355 BS Plus Ritonavir in Healthy Volunteers

Inclusion Criteria: * Males and Females who meet the inclusion/exclusion criteria; females must not be pregnant or nursing, and must agree to use a double-barrier method of birth control (condoms or diaphragm, plus spermicide) throughout the trial (alone or in addition to other methods of birth control such as oral contraceptives) * Age ≥18 and \<60 years * Body Mass Index (BMI) ≥18.5 and BMI ≤29.9 kg/m2 * Ability to give signed and dated written informed consent prior to admission to the study in accordance with good clinical practice (GCP) and the local regulations Exclusion Criteria: * Current (symptomatic within the last 30 days) and medically relevant gastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disorders * Surgery of gastrointestinal tract (except appendectomy) * Currently active (symptomatic within the last 30 days) diseases of the central nervous system (such as epilepsy) or psychiatric disorders or neurological disorders * History of relevant orthostatic hypotension, fainting spells or blackouts * History of allergy/hypersensitivity (including drug allergy) which is deemed relevant to the trial as judged by the investigator * Intake of drugs with a long half-life (\>24 hours) within one month prior to administration of study drug or during the trial (review with clinical monitor if questionable) * Use of drugs within 10 days prior to administration or during the trial, which might reasonably influence the results of the trial based on the knowledge at the time of protocol preparation (review with clinical monitor if questionable) * Participation in another trial with an investigational drug within one month prior to administration or during the trial * Current smoker * Alcohol (more than 60 g/day) or drug abuse (positive urine test for illicit prescription or non-prescription drugs or drugs of abuse) * Recent blood donation (more than 100 mL within 4 weeks prior to administration or during the trial) * Excessive physical activities (within 1 week prior to study drug administration or during the trial) * Any laboratory value outside the normal reference range that is of clinical relevance at screening, according to the judgment of the investigator * Inability to comply with dietary regimen required by the protocol * Chronic or relevant acute infections * Infected with hepatitis B or hepatitis C viruses (defined as either being hepatitis B surface antigen, or hepatitis C antibody positive) * HIV-1 infected as defined by a positive HIV ELISA test